Atherogenesis: Initiating Factors

Atherogenesis: Initiating Factors

This symposium on mechanisms in the development of early atheroma was held at the Ciba Foundation in London, July 5-6, 1972. For American students of atherosclerosis it differs both in the composition of the panel and in the selection of areas discussed. Only three of the 22 participants are from the United States. Eleven are from the United Kingdom, three from elsewhere in Europe, three from I...

Geometric factors of the bifurcation in carotid atherogenesis.

In vitro studies have demonstrated that geometry of the carotid bifurcation predicts blood flow alterations associated with atherosclerotic plaque formation. We investigated intraindividual asymmetry of carotid atherosclerosis by measuring geometric aspects of the carotid bifurcation. We measured diameter stenosis, the internal carotid artery/common carotid artery area ratio, and the angle of t...

Initiating factors of gallstones, especially cholesterol stones. II.

Factors associated with initiating someone into illicit drug injection.

AIMS Most people who inject drugs (PWID) were first initiated into injection by a current PWID. Few studies have examined PWID who assist others into drug injection. Our goal is to describe the prevalence of and risk factors for initiating someone into injection in the last 12 months. METHODS We recruited a cross-sectional sample of PWID (N=605) in California from 2011 to 2013. We examined bi...

Ferns and Heikal, Atherogenesis and hypoxia Hypoxia in Atherogenesis

The anoxemia theory proposes that an imbalance between the demand for, and supply of, oxygen in the arterial wall is a key factor in the development of atherosclerosis. There is now substantial evidence that there are regions within the atherosclerotic plaque in which profound hypoxia exists; this may fundamentally change the function, metabolism and responses of many of the cell types found wi...